NTQ1062
Modify Date: 2024-01-02 16:10:03
NTQ1062 structure
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Common Name | NTQ1062 | ||
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| CAS Number | 2459489-66-6 | Molecular Weight | 483.01 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H31ClN6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NTQ1062NTQ1062 (compound 22b) is a potent and orally active Akt inhibitor with IC50s of 0.4 nM, 6.3 nM and 0.1 nM for Akt1, Akt2 and Akt3, respectively. NTQ1062 induces cell apoptosis and arrests the cell cycle at G0/G1 phase. NTQ1062 exhibits antiproliferation activity against various cancer cells. NTQ1062 exhibits potent antitumor efficacy in LNCap xenograft mouse model[1]. |
| Name | NTQ1062 |
|---|
| Description | NTQ1062 (compound 22b) is a potent and orally active Akt inhibitor with IC50s of 0.4 nM, 6.3 nM and 0.1 nM for Akt1, Akt2 and Akt3, respectively. NTQ1062 induces cell apoptosis and arrests the cell cycle at G0/G1 phase. NTQ1062 exhibits antiproliferation activity against various cancer cells. NTQ1062 exhibits potent antitumor efficacy in LNCap xenograft mouse model[1]. |
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| Related Catalog | |
| Target |
Akt1:0.4 nM (IC50) Akt2:6.3 nM (IC50) Akt3:0.1 nM (IC50) |
| In Vivo | Pharmacokinetic Parameters of NTQ1062 in male Sprague-Dawley rats[1]. IV (5 mg/kg) IG (10 mg/kg) Tmax (h) 2 t1/2 (ng/mL) 2.97 3.28 Cmax (ng/mL) 1691 705 AUC0-t (ng/mL·h) 1761 3877 AUC0-∞ (ng/mL·h) 1801 3891 VSS (L/kg) 7.76 F (%) 110 |
| References |
| Molecular Formula | C25H31ClN6O2 |
|---|---|
| Molecular Weight | 483.01 |