2408800-91-7

2408800-91-7 structure

Name: Anticancer agent 55
Chemical Name: Anticancer agent 55
CAS Number: 2408800-91-7
Molecular Formula: C₂₈H₂₁Br₂FN₂O₂
Molecular Weight: 596.28
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2022-07-02 15:44:57
Modify Date: 2024-01-30 15:07:35
Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer[1].

Name	Anticancer agent 55

Description	Anticancer agent 55 is a potent anticancer agent. Anticancer agent 55 shows anticancer activity via reducing the cell viability and cell migration in a dose-dependent manner. Anticancer agent 55 induces apoptosis. Anticancer agent 55 has the potential for the research of prostate cancer and breast cancer[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer
In Vitro	Anticancer agent 55 (compound 3h) (0-100 µM; 48 h) inhibits cell viability with IC50s of 1.18 µM and 1.95 µM for PC-3, MCF-7 cells, respectively[1]. Anticancer agent 55 (0, 1, 3, 10 µM; 24 h) inhibits cell migration of PC-3 cells and MCF-7 cells in a dose-dependent manner[1]. Anticancer agent 55 (0, 1, 3, 10 µM; 12, 24 h) induces apoptosis by increases the caspase-3 activity and cleaved PARP levels[1]. Cell Viability Assay[1] Cell Line: PC-3, MCF-7 cells Concentration: 0-100 µM Incubation Time: 48 h Result: Significantly inhibited cell viability of PC-3, MCF-7 cells with IC50s of 1.18 µM and 1.95 µM, respectively. Apoptosis Analysis[1] Cell Line: PC-3, MCF-7 cells Concentration: 0, 1, 3, 10 µM Incubation Time: PC-3 for 12 h; MCF-7 for 24 h Result: Induced apoptosis by increased the caspase-3 activity in a concentration-dependent manner. Western Blot Analysis[1] Cell Line: PC-3, MCF-7 cells Concentration: 0, 1, 3, 10 µM Incubation Time: PC-3 for 12 h; MCF-7 for 24 h Result: Increased cleaved PARP levels in a dose-dependent manner in PC-3 and MCF-7 cells.
References	[1]. Seo Y, et al. Expansion of chemical space based on a pyrrolo[1,2-a]pyrazine core: Synthesis and its anticancer activity in prostate cancer and breast cancer cells. Eur J Med Chem. 2020 Feb 15;188:111988.

Molecular Formula	C₂₈H₂₁Br₂FN₂O₂
Molecular Weight	596.28

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