94205-22-8

94205-22-8 structure

94205-22-8 structure

Name: Anticancer agent 93
Chemical Name: Anticancer agent 93
CAS Number: 94205-22-8
Molecular Formula: C₁₆H₁₀ClNO₄
Molecular Weight: 315.71
Catalog: Research Areas Cancer
Create Date: 2023-02-03 19:45:30
Modify Date: 2024-01-16 09:42:14
Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1].

Name	Anticancer agent 93

Description	Anticancer agent 93 is a 4-Hydroxycoumarin derivative. Anticancer agent 93 can inhibit invasion and migration of lung cancer cells by modulating expression of epithelial-mesenchymal transition (EMT) effectors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Anticancer agent 93 (compound 4h) (5-15 μM; 24 h) significantly inhibits A549 cell invasion by ~ 50%[1]. Anticancer agent 93 (15 μM; 24-72 h) significantly inhibits A549 cell migration[1]. Anticancer agent 93 (5-15 μM; 4 h) inhibits lung cancer cell motility by downregulating EMT markers[1]. Western Blot Analysis[1] Cell Line: A549 cells Concentration: 5, 10, 15 μM Incubation Time: 24 hours Result: Decreased expression of N-cadherin and E-cadherin.
References	[1]. Zhou R, et, al. Synthesis of coumarin derivatives and investigation of their inhibitory effects on lung cancer cell motility. Sci Rep. 2022 Dec 14;12(1):21635.

Molecular Formula	C₁₆H₁₀ClNO₄
Molecular Weight	315.71