388101-58-4
388101-58-4 structure
- Name: BMS-570520
- Chemical Name: BMS-570520
- CAS Number: 388101-58-4
- Molecular Formula: C27H36FN5O3S
- Molecular Weight: 529.675
- Create Date: 2022-07-01 15:48:08
- Modify Date: 2024-01-18 12:09:31
-
BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.BMS-570520 displays reduced inhibition on CYP2D6 (IC50=1300 nM) compared with DPC168 (IC50=30 nM), also possesses >100-fold selectivity over 5-HT2a, DAT and NET.BMS-570520 showed good activity in murine models of CCR3 antagonism and greater in vitro potency and in vivo in the mouse intranasal eotaxin challenge mode.
| Name | BMS-570520 |
|---|
| Description | BMS-570520 is a potent, selective CCR3 antagonist with IC50 of 1.9 nM, inhibits eotaxin-induced chemotaxis with IC50 of 0.068 nM.BMS-570520 displays reduced inhibition on CYP2D6 (IC50=1300 nM) compared with DPC168 (IC50=30 nM), also possesses >100-fold selectivity over 5-HT2a, DAT and NET.BMS-570520 showed good activity in murine models of CCR3 antagonism and greater in vitro potency and in vivo in the mouse intranasal eotaxin challenge mode. |
|---|---|
| References | 1. James R Pruitt, et al. Bioorg Med Chem Lett. 2007 Jun 1;17(11):2992-7. |
| Molecular Formula | C27H36FN5O3S |
|---|---|
| Molecular Weight | 529.675 |