752237-69-7
752237-69-7 structure
- Name: BI-1124
- Chemical Name: BI-1124
- CAS Number: 752237-69-7
- Molecular Formula: C22H39N5O3
- Molecular Weight: 421.586
- Create Date: 2022-07-02 17:52:32
- Modify Date: 2025-08-25 09:02:51
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BI-1124 (BI 1124) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 7 nM, >40-fold selectivity over Cathepsin L/K/B;BI-1124 had a superior PK profile and showed dose-dependent inhibition of the ovalbumin induced IL-2 secretion in a T cell receptor transgenic DO11 mouse model with an IC50 of 0.3 mg/kg.
| Name | BI-1124 |
|---|
| Description | BI-1124 (BI 1124) is a highly potent, selective inhibitor of Cathepsin S (CatS) with IC50 of 7 nM, >40-fold selectivity over Cathepsin L/K/B;BI-1124 had a superior PK profile and showed dose-dependent inhibition of the ovalbumin induced IL-2 secretion in a T cell receptor transgenic DO11 mouse model with an IC50 of 0.3 mg/kg. |
|---|
| Molecular Formula | C22H39N5O3 |
|---|---|
| Molecular Weight | 421.586 |