2710273-81-5
2710273-81-5 structure
- Name: HDAC3 inhibitor PT3
- Chemical Name: HDAC3 inhibitor PT3
- CAS Number: 2710273-81-5
- Molecular Formula: C18H17N5O
- Molecular Weight: 319.368
- Create Date: 2022-07-01 18:58:14
- Modify Date: 2024-01-06 22:29:17
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HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.PT3 upregulated H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells.PT3 significantly improved the discrimination index in C57/BL6 mice in the novel object recognition (NOR) model, significant increased in H3K9 acetylation in hippocampus.PT3 upregulated CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3.
| Name | HDAC3 inhibitor PT3 |
|---|
| Description | HDAC3 inhibitor PT3 is a novel potent, selective, BBB-permeable HDAC3 inhibitor.PT3 exhibited higher selectivity for HDAC3 over HDAC1, HDAC6, and HDAC8 compared to the reference compound CI994.PT3 upregulated H3K9 acetylation, CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43 and MMP9 expression in mouse neuronal (N2A) cells.PT3 significantly improved the discrimination index in C57/BL6 mice in the novel object recognition (NOR) model, significant increased in H3K9 acetylation in hippocampus.PT3 upregulated CREB 1, BDNF, TRKB, Nr4a2, c-fos, PKA, GAP 43, PSD 95 and MMP9 expression in mice treated with PT3. |
|---|---|
| References | 1. Sravani Pulya, et al. ACS Chem Neurosci. 2021 Mar 3;12(5):883-892. |
| Molecular Formula | C18H17N5O |
|---|---|
| Molecular Weight | 319.368 |