2403716-19-6

2403716-19-6 structure

Name: Steroid sulfatase-IN-1
Chemical Name: Steroid sulfatase-IN-1
CAS Number: 2403716-19-6
Molecular Formula: C₁₄H₁₀Cl₂N₄O₃S
Molecular Weight: 385.23
Catalog: Research Areas Cancer
Create Date: 2022-05-24 12:10:30
Modify Date: 2024-01-14 21:07:59
Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfatase-IN-1 shows antitumor activity (TGI=51%) in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].

Name	Steroid sulfatase-IN-1

Description	Steroid sulfatase-IN-1 is a potent and orally active Steroid sulfatase inhibitor with an IC50 of 1.71 µM. Steroid sulfatase-IN-1 shows antitumor activity (TGI=51%) in vivo. Steroid sulfatase-IN-1 has the potential for the research of breast cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
Target	IC50: 1.71 µM (Steroid sulfatase)[1]
In Vivo	Steroid sulfatase-IN-1 (compound 4 b) (50 mg/kg; p.o.) shows significant antitumor activity with the TGI value of 51%[1]. Animal Model: 67NR mouse[1] Dosage: 50 mg/kg Administration: P.o. Result: Showed significant antitumor activity with the TGI value of 51%.
References	[1]. Biernacki K, et al. Development of Sulfamoylated 4-(1-Phenyl-1H-1,2,3-triazol-4-yl)phenol Derivatives as Potent Steroid Sulfatase Inhibitors for Efficient Treatment of Breast Cancer. J Med Chem. 2022; 65(6):5044-5056.

Molecular Formula	C₁₄H₁₀Cl₂N₄O₃S
Molecular Weight	385.23