2695505-82-7

2695505-82-7 structure
2695505-82-7 structure
  • Name: RAF-IN-1
  • Chemical Name: RAF-IN-1
  • CAS Number: 2695505-82-7
  • Molecular Formula: C26H22F3N3O4
  • Molecular Weight: 497.47
  • Create Date: 2022-07-09 15:57:04
  • Modify Date: 2025-08-26 20:59:35
  • RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].

Name RAF-IN-1
Description RAF-IN-1 is a potent b/cRAF inhibitor with an IC50s of 3.8 nM, 36 nM, 29.4 nM for cRAF, bRAFwt, and bRAFV600E. RAF-IN-1 shows cell growth inhibition with GI50s of 3.4 and 2.9 nM for H358 and A375 cell line bearing bRAFV600E mutation, respectively[1].
Related Catalog
Target

BRafV600E:29.4 nM (IC50)

BRAFWT:36 nM (IC50)

c-Raf:3.8 nM (IC50)

References

[1]. Zhao P, et al. Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers. Eur J Med Chem. 2022;228:114040.

Molecular Formula C26H22F3N3O4
Molecular Weight 497.47
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