2499965-12-5
2499965-12-5 structure
- Name: PD-1/PD-L1-IN-14
- Chemical Name: PD-1/PD-L1-IN-14
- CAS Number: 2499965-12-5
- Molecular Formula: C24H24N4O2
- Molecular Weight: 400.47
- Create Date: 2022-05-20 13:03:53
- Modify Date: 2025-08-23 21:12:49
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PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1].
| Name | PD-1/PD-L1-IN-14 |
|---|
| Description | PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1]. |
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| Related Catalog | |
| Target |
IC50： 27.8 nM (PD-1/PD-L1)[1]. |
| In Vitro | PD-1/PD-L1-IN-14 (compound 17) promotes cell-surface PD-L1 internalized into the cytosol and induces the degradation of PD-L1 in tumor cells through a lysosome-dependent pathway[1]. |
| References |
| Molecular Formula | C24H24N4O2 |
|---|---|
| Molecular Weight | 400.47 |