2667680-33-1
2667680-33-1 structure
- Name: PD-1/PD-L1-IN-24
- Chemical Name: PD-1/PD-L1-IN-24
- CAS Number: 2667680-33-1
- Molecular Formula: C34H30ClN5O6
- Molecular Weight: 640.08
- Catalog: Signaling Pathways Immunology/Inflammation PD-1/PD-L1
- Create Date: 2022-05-21 15:55:34
- Modify Date: 2024-01-02 11:59:12
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PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs[1].
| Name | PD-1/PD-L1-IN-24 |
|---|
| Description | PD-1/PD-L1-IN-24 is a highly potent PD-1/PD-L1 inhibitor with IC50 value of 1.57 nM. PD-1/PD-L1-IN-24 can restore T-cell function at the cellular level by significantly elevating the IFN-γ level. PD-1/PD-L1-IN-24 has low toxicity on the PBMCs[1]. |
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| Related Catalog | |
| Target |
IC50: 1.57 nM (PD-1/PD-L1)[1] |
| In Vitro | PD-1/PD-L1-IN-24 (compound 39) (0-10 μM; 6 hours) significantly releases PD-L1-mediated inhibition of PD-1-expressing Jurkat T cells at the concentration of 10 μM[1]. PD-1/PD-L1-IN-24 (0.003-20 μM; 72 hours) exhibits no significant toxicity at concentrations ranging from 0.003 to 2.22 μM, and the IC50 is 12.42 μM[1]. PD-1/PD-L1-IN-24 (0.082, 0.247, 0.741 and 2.222 μM; 72 hours) significantly elevates the secretion of IFN-γ with a dose-dependent manner in T cell-tumor co-culture cells[1]. Cell Cytotoxicity Assay Cell Line: PBMC[1] Concentration: 0.003, 0.0091, 0.027, 0.082, 0.247, 0.741, 2.222, 6.67 and 20 μM Incubation Time: 72 hours Result: No significant toxicity was observed at concentrations ranging from 0.003 to 2.22 μM, and the IC50 was 12.42 μM. |
| References |
| Molecular Formula | C34H30ClN5O6 |
|---|---|
| Molecular Weight | 640.08 |