2377491-54-6

2377491-54-6 structure

Name: AGI-43192
Chemical Name: AGI-43192
CAS Number: 2377491-54-6
Molecular Formula: C₂₃H₁₆ClF₃N₆O
Molecular Weight: 484.86
Create Date: 2022-05-21 07:05:48
Modify Date: 2025-08-25 09:01:01
AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].

Name	AGI-43192

Description	AGI-43192 is a potent inhibitor of methionine adenosyltransferase 2A (MAT2A). AGI-43192 is a potent, but limited brain-penetrant compound. AGI-43192 has the potential for exploring the effects of SAM modulation in the central nervous system (CNS) and research of cancer disease[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Somatostatin Receptor Research Areas >> Neurological Disease
References	[1]. Li M, et al. Leveraging Structure-Based Drug Design to Identify Next-Generation MAT2A Inhibitors, Including Brain-Penetrant and Peripherally Efficacious Leads. J Med Chem. 2022;65(6):4600-4615.

Molecular Formula	C₂₃H₁₆ClF₃N₆O
Molecular Weight	484.86