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2406276-78-4

2406276-78-4 structure
2406276-78-4 structure
  • Name: OM-1700
  • Chemical Name: OM-1700
  • CAS Number: 2406276-78-4
  • Molecular Formula: C25H23FN6O2
  • Molecular Weight: 458.49
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
  • Create Date: 2022-04-06 18:16:48
  • Modify Date: 2024-01-10 06:47:12
  • OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].
Name OM-1700
Description OM-1700 is a potent tankyrase inhibitor with IC50s of 127 and 14 nM for tankyrase 1 and tankyrase 2, respectively. OM-1700 reduces cell growth in the colon cancer cell line COLO 320DM (GI50=650 nM)[1].
Related Catalog
Target

TNKS1:127 nM (IC50)

TNKS2:14 nM (IC50)

In Vitro OM-153 shows inhibition (IC50=19 nM) in a cellular (HEK293) WNT/β-catenin signaling reporter assay[1].
References

[1]. Leenders RGG, et al. Development of a 1,2,4-Triazole-Based Lead Tankyrase Inhibitor: Part II. J Med Chem. 2021;64(24):17936-17949.

Molecular Formula C25H23FN6O2
Molecular Weight 458.49

Chemsrc provides CAS#:2406276-78-4 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 2406276-78-4 | Chemsrc address: https://www.chemsrc.com/en/baike/1704930.html

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