163958-73-4

163958-73-4 structure

Name: TAPI-0
Chemical Name: TAPI 0
CAS Number: 163958-73-4
Molecular Formula: C₂₄H₃₂N₄O₅
Molecular Weight: 456.53
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2022-03-26 19:06:10
Modify Date: 2024-01-22 17:15:55
TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].

Name	TAPI 0
Synonyms	N-[(2R)-2-[2-(Hydroxyamino)-2-oxoethyl]-4-methyl-1-oxopentyl]-3-(2-naphthalenyl)-L-alanyl-L-alaninamide TAPI-0 TNF-α Protease Inhibitor-0 N-(R)-(2-(Hydroxyaminocarbonyl)Methyl)-4-Methylpentanoyl-L-Naphthylalanyl-L-Alanine amide MFCD02684279 TNF-α Processing Inhibitor-0

Description	TAPI-0 is a TACE (TNF-α converting enzyme; ADAM17) inhibitor with an IC50 of 100 nM. TAPI-0 is a MMP inhibitor and also attenuates TNF-α processing[1][2].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Anti-infection >> Bacterial
Target	IC50: 100 nM (TACE)[2]
In Vitro	TAPI-0 inhibits peptide deformylase (PDF) with an IC50 of 18 nM. TAPI-0 suppresses chlamydial growth by targeting the bacterial PDF[1].
References	[1]. Amit Balakrishnan, et al. Metalloprotease inhibitors GM6001 and TAPI-0 inhibit the obligate intracellular human pathogen Chlamydia trachomatis by targeting peptide deformylase of the bacterium. J Biol Chem. 2006 Jun 16;281(24):16691-9. [2]. Shiori Haga, et al. TACE antagonists blocking ACE2 shedding caused by the spike protein of SARS-CoV are candidate antiviral compounds. Antiviral Res. 2010 Mar;85(3):551-5.