1259536-62-3
1259536-62-3 structure
- Name: QO 58
- Chemical Name: QO 58
- CAS Number: 1259536-62-3
- Molecular Formula: C18H8Cl2F4N4O
- Molecular Weight: 443.18
- Create Date: 2022-05-27 10:43:03
- Modify Date: 2025-08-25 15:52:19
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QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1].
| Name | QO 58 |
|---|---|
| Synonyms |
5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one
Pyrazolo[1,5-a]pyrimidin-7(4H)-one, 5-(2,6-dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)- QO-58 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one |
| Description | QO 58 is a potent modulator of K(v)7 channels. QO-58 increases the current amplitudes, shifts the voltage-dependent activation curve in a more negative direction and slows the deactivation of K(v)7.2/K(v)7.3 currents. QO-58 has the potential for the research of diseases associated with neuronal hyperexcitability[1]. |
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| Related Catalog | |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 568.5±60.0 °C at 760 mmHg |
| Molecular Formula | C18H8Cl2F4N4O |
| Molecular Weight | 443.18 |
| Flash Point | 297.6±32.9 °C |
| Exact Mass | 442.001129 |
| LogP | 4.92 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.663 |