2170140-50-6

2170140-50-6 structure

Name: (R)-GSK-3685032
Chemical Name: (R)-GSK-3685032
CAS Number: 2170140-50-6
Molecular Formula: C₂₂H₂₄N₆OS
Molecular Weight: 420.53
Catalog: Signaling Pathways Epigenetics DNA Methyltransferase
Create Date: 2022-02-20 17:13:20
Modify Date: 2024-01-14 13:08:37
(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].

Name	(R)-GSK-3685032

Description	(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	DNMT1
References	[1]. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727. [2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.

Molecular Formula	C₂₂H₂₄N₆OS
Molecular Weight	420.53