(R)-GSK-3685032

Modify Date: 2024-01-14 13:08:37

(R)-GSK-3685032 structure	Common Name	(R)-GSK-3685032
	CAS Number	2170140-50-6	Molecular Weight	420.53
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₂H₂₄N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (R)-GSK-3685032

(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].

Name	(R)-GSK-3685032

Description	(R)-GSK-3685032 is the R-enantiomer of GSK-3685032. GSK-3685032 is a non-time-dependent, noncovalently, first-in-class reversible DNMT1-selective inhibitor, with an IC50 of 0.036 μM. GSK-3685032 induces robust loss of DNA methylation, transcriptional activation, and cancer cell growth inhibition[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> DNA Methyltransferase
Target	DNMT1
References	[1]. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727. [2]. Pappalardi MB, et al. Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. Nat Cancer. 2021;2(10):1002-1017.

Molecular Formula	C₂₂H₂₄N₆OS
Molecular Weight	420.53

(R)-GSK-3685032

Use of (R)-GSK-3685032

Names

(R)-GSK-3685032 Biological Activity

Chemical & Physical Properties