2102194-04-5
2102194-04-5 structure
- Name: MK-6884
- Chemical Name: MK-6884
- CAS Number: 2102194-04-5
- Molecular Formula: C25H25N5O
- Molecular Weight: 411.50
- Catalog: Signaling Pathways GPCR/G Protein mAChR
- Create Date: 2022-03-12 10:02:54
- Modify Date: 2024-01-09 18:26:15
-
MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent[1].
| Name | MK-6884 |
|---|
| Description | MK-6884 is a M4 muscarinic receptor positive allosteric modulator (PAM) with a Ki value of 0.19 nM. MK-6884 can be used for the research of the neurodegenerative diseases. MK-6884 can be conveniently radiolabeled with carbon-11 and as a positron emission tomography (PET) imaging agent[1]. |
|---|---|
| Related Catalog | |
| Target |
M4 muscarinic receptor[1] |
| In Vitro | MK-6884 (compound 13; 0-22 µM) is a PAM of ACh function in a cell-based Ca2+ mobilization assay, with an EC50 of 27 nM[1]. |
| In Vivo | [11C]MK-6884 (compound 13) shows non-displaceable binding potential (BPND) of 0.83 in rhesus monkeys[1]. [11C]MK-6884 (approximately 185 MBq, <2 μg; single intravenous) distributes on the known presence of M4 receptors in the rhesus monkeys brain[1]. [11C]MK-688 can penetrate the blood-brain barrier in monkeys[1]. |
| References |
| Molecular Formula | C25H25N5O |
|---|---|
| Molecular Weight | 411.50 |