Shanghai Nianxing Industrial Co., Ltd
China
Product Name: ABT-384
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: ABT-384
Price: $Inquiry/100mg ￥Inquiry/250mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

868623-40-9

868623-40-9 structure

868623-40-9 structure

Name: ABT-384
Chemical Name: ABT-384
CAS Number: 868623-40-9
Molecular Formula: C₂₅H₃₄F₃N₅O₂
Molecular Weight: 493.56
Catalog: Research Areas Others
Create Date: 2022-01-06 18:46:12
Modify Date: 2024-01-24 13:11:07
ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM[1][2].

Name	ABT-384

Description	ABT-384 is a selective 11-β-hydroxysteroid dehydrogenase type 1 (HSD-1) inhibitor. ABT-384 blocks regeneration of active cortisol. ABT-384 exhibits high affinity against rodent, monkey, and human HSD-1 whit a Ki of 0.1-2.7 nM[1][2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease Research Areas >> Neurological Disease
In Vivo	ABT-384 can be used for the research of the Cushing’s syndrome, obesity, insulin resistance, hypertension, dyslipidemia, osteoporosis, glaucoma, major depressive disorder, and Alzheimer’s disease (AD) [2] .
References	[1]. [1] Katz DA, et al. Peripheral and central nervous system inhibition of 11β-hydroxysteroid dehydrogenase type 1 in man by the novel inhibitor ABT-384. Transl Psychiatry. 2013;3(8):e295. Published 2013 Aug 27. [2]. [2] Liu W, et al. Clinical Safety, Pharmacokinetics, and Pharmacodynamics of the 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor ABT-384 in Healthy Volunteers and Elderly Adults. Clin Pharmacol Drug Dev. 2013;2(2):133-151.

Molecular Formula	C₂₅H₃₄F₃N₅O₂
Molecular Weight	493.56

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