2072901-32-5
2072901-32-5 structure
- Name: Rovanersen
- Chemical Name: Rovanersen
- CAS Number: 2072901-32-5
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Neurological Disease
- Create Date: 2022-02-09 10:49:21
- Modify Date: 2024-01-14 22:41:08
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Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research[1].
| Name | Rovanersen |
|---|
| Description | Rovanersen (WVE-120101) is an antisense oligonucleotide that can be used for huntington’s disease research[1]. |
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| Related Catalog | |
| In Vitro | In vitro, Rovanersen (WVE-120101) leads to the selective RNase H cleavage of mutant Huntingtin allele (mHTT) over wtHTT, with no complement activation. Rovanersen selectively decreases mHTT mRNA and protein levels compared with wtHTT in multiple cells lines[1]. |
| In Vivo | In non-human primates (NHPs), Rovanersen (WVE-120101) is found in nuclear and perinuclear compartments of neurons in brain areas believed to be involved in HD pathology[1]. |
| References |
| No Any Chemical & Physical Properties |