1496508-34-9
1496508-34-9 structure
- Name: Dazucorilant
- Chemical Name: Dazucorilant
- CAS Number: 1496508-34-9
- Molecular Formula: C29H22F4N4O3S
- Molecular Weight: 582.57
- Catalog: Signaling Pathways GPCR/G Protein Glucocorticoid Receptor
- Create Date: 2022-01-09 11:33:02
- Modify Date: 2025-08-26 15:07:28
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Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2].
| Name | Dazucorilant |
|---|
| Description | Dazucorilant (CORT113176) is a selective and high affinity non-steroidal glucocorticoid receptor (GR) modulator with a Ki value ＜1 nM in vitro. Dazucorilant can be used for the research of neurological disorders[1][2]. |
|---|---|
| Related Catalog | |
| Target |
GR[1] |
| In Vitro | In HepG2 human cells or in human hepatocytes, Dazucorilant acts as full antagonist since it is able to prevent the dexamethasone-induced increase in TAT activity and to induce non-measurable agonist activity in the absence of dexamethasone[3]. |
| In Vivo | Dazucorilant (30 mg/kg/day; s.c.) makes mice show reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity[1]. Dazucorilant (5, 10 or 20 mg/kg; i.p.) reverses hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restores the hippocampal levels of synaptic markers, reestablishes basal plasma levels of glucocorticoids and improves cognitive function at a dose of 10 mg/kg[2]. Animal Model: Wobbler mice (five-month-old)[1] Dosage: 30 mg/kg/day Administration: S.c. Result: Wobbler mice showed reversed abnormalities of motoneurons and down-regulated proinflammatory mediators and glial reactivity. Animal Model: Adult SD male rats[2] Dosage: 5, 10 or 20 mg/kg Administration: I.p. Result: Reversed hippocampal amyloid-β peptide generation, neuroinflammation and apoptotic processes, restored the hippocampal levels of synaptic markers, reestablished basal plasma levels of glucocorticoids and improved cognitive function at a dose of 10 mg/kg. |
| References |
| Molecular Formula | C29H22F4N4O3S |
|---|---|
| Molecular Weight | 582.57 |