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68547-97-7 64603-90-3
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68547-97-7

68547-97-7 structure
68547-97-7 structure
Name 1,2,3,6-Tetrahydro-4-pyridinecarboxylic Acid Hydrochloride
Synonyms 1,2,3,6-tetrahydropyridine-4-carboxylic acid,hydrochloride
Isoguvacine (hydrochloride)
Isoguvacine Hydrochloride
Description Isoguvacine hydrochloride is a GABA receptor agonist.
Related Catalog
Target

GABA[1]
In Vitro Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus[1]. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA[2]. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently[3].
Kinase Assay The assay for 3H-Isoguvacine binding is carried out as follows: membranes suspended in Tris-citrate buffer pH 7.1 are incubated at 4°C for 10 min with 8 nM 3H-Isoguvacine. Identical samples are incubated in the presence of cold 0.5 mM GABA or 10 μM cold isoguvacine. The assay is terminated by centrifugation for 10 min at 4°C in a micro-centrifuge. The supernatants are rapidly aspirated and the surface of the pellets washed (2x) with ice-cold buffer. The pellet is resuspended in I00 μL of 0.1% Triton and placed in a scintillation vial. The assay tube is washed with I00 μL of distilled water and the wash added to the vial along with 10 ml of PCS: xylene (2:1). Counting efficiency is determined to be 40-45% in a Beckman liquid scintillation counter. Specific binding is defined as those radioactive cpm of bound 3H-Isoguvacine that are displaced by excess cold isoguvacine or GABA[1].
References

[1]. Morin AM, et al. The binding of 3H-isoguvacine to mouse brain synapticmembranes. Life Sci. 1980 Apr 14;26(15):1239-45.

[2]. White WF, et al. Isoguvacine binding, uptake, and release: relation to the GABA system. J Neurochem. 1983 Jun;40(6):1701-8.

[3]. Wahab A, et al. Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 2009 Oct;86(2-3):113-23.

Molecular Formula C6H10ClNO2
Molecular Weight 163.60200
Exact Mass 163.04000
PSA 49.33000
LogP 1.12150
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
RIDADR NONH for all modes of transport
503544-95-4 structure

503544-95-4

~%

68547-97-7 structure

68547-97-7
Literature: Heterocycles, , vol. 57, # 12 p. 2321 - 2334
158984-76-0 structure

158984-76-0

~%

68547-97-7 structure

68547-97-7
Literature: Heterocycles, , vol. 57, # 12 p. 2321 - 2334
503545-00-4 structure

503545-00-4

~%

68547-97-7 structure

68547-97-7
Literature: Heterocycles, , vol. 57, # 12 p. 2321 - 2334
76309-83-6 structure

76309-83-6

~%

50-00-0 structure

50-00-0
68547-97-7 structure

68547-97-7
Literature: Journal of Medicinal Chemistry, , vol. 24, # 3 p. 285 - 289
1293370-62-3 structure

1293370-62-3

~98%

68547-97-7 structure

68547-97-7
Literature: Reeves, Diana C.; Rodriguez, Sonia; Lee, Heewon; Haddad, Nizar; Krishnamurthy, Dhileepkumar; Senanayake, Chris H. Organic Letters, 2011 , vol. 13, # 9 p. 2495 - 2497
79858-48-3 structure

79858-48-3

~51%

68547-97-7 structure

68547-97-7
Literature: Chang, Meng-Yang; Chen, Shui-Tein; Chang, Nein-Chen Heterocycles, 2002 , vol. 57, # 12 p. 2321 - 2334

Chemsrc provides CAS#:68547-97-7 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 68547-97-7 | Chemsrc address: https://www.chemsrc.com/en/baike/168216.html

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