1217655-71-4

1217655-71-4 structure

Name: Epi-galanthamine-O-methyl-d3
Chemical Name: Epi-galanthamine-O-methyl-d3
CAS Number: 1217655-71-4
Molecular Formula: C₁₇H₁₈D₃NO₃
Molecular Weight: 290.37
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2021-10-14 21:42:09
Modify Date: 2024-01-09 18:24:57
Epi-galanthamine-O-methyl-d3 is the deuterium labeled Epi-galantamine. Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM[1][2][3].

Name	Epi-galanthamine-O-methyl-d3

Description	Epi-galanthamine-O-methyl-d3 is the deuterium labeled Epi-galantamine. Epi-galantamine is a diastereomer of Galantamine. Epi-galantamine is an alkaloid isolated from the bulbs and flowers of Caucasian snowdrop (Galanthus woronowii). Epi-galantamine inhibits AChE with an EC50 of 45.7 μM[1][2][3].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Thomsen T, et al. Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans. Eur J Clin Pharmacol. 1990;39(6):603-5. [3]. Berkov S, et al. Rapid TLC/GC-MS identification of acetylcholinesterase inhibitors in alkaloid extracts. Phytochem Anal. 2008 Sep-Oct;19(5):411-9. [4]. Maláková J, et al. High-performance liquid chromatographic method with UV photodiode-array, fluorescence and mass spectrometric detection for simultaneous determination of galantamine and its phase I metabolites in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Jun 15;853(1-2):265-74.

Molecular Formula	C₁₇H₁₈D₃NO₃
Molecular Weight	290.37