134467-58-6

134467-58-6 structure

Name: 2-NAPHTHALENAMINE, 1,2,3,4-TETRAHYDRO-N-2-PROPYNYL-, HYDROCHLORIDE
Chemical Name: N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)
CAS Number: 134467-58-6
Molecular Formula: C₁₃H₁₆ClN
Molecular Weight: 221.726
Catalog: Signaling Pathways Neuronal Signaling Monoamine Oxidase
Create Date: 2021-09-10 14:10:54
Modify Date: 2025-09-02 21:22:47
2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC50 of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC50 of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research[1].

Name	N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1)
Synonyms	N-(2-Propyn-1-yl)-1,2,3,4-tetrahydro-2-naphthalenamine hydrochloride (1:1) MFCD09998861 2-Naphthalenamine, 1,2,3,4-tetrahydro-N-2-propyn-1-yl-, hydrochloride (1:1)

Description	2-PAT, an analogue of Rasagiline and Selegiline, a reversible MAO-A inhibitor with an IC50 of 0.721 µM. 2-PAT is an inactivator of MAO-B with an IC50 of 14.6 µM. 2-PAT has the potential for Parkinson’s disease and depression research[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase Research Areas >> Neurological Disease
Target	MAO-A:0.721 μM (IC50) MAO-B:14.6 μM (IC50)
References	[1]. Letitia Meiring, et al. The evaluation of N-propargylamine-2-aminotetralin as an inhibitor of monoamine oxidase. Bioorg Med Chem Lett. 2022 Jul 1;67:128746.