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Product Name: phyllomedusin
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26145-48-2

26145-48-2 structure

26145-48-2 structure

Name: phyllomedusin
Chemical Name: phyllomedusin
CAS Number: 26145-48-2
Molecular Formula: C₅₂H₈₂N₁₆O₁₃S
Molecular Weight: 1171.372
Catalog: Signaling Pathways GPCR/G Protein Neurokinin Receptor
Create Date: 2021-09-25 07:40:38
Modify Date: 2025-08-25 19:45:12
Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus[1][2][3].

Name	phyllomedusin

Description	Phyllomedusin, an tachykinin decapeptide, is a NK1 receptor agonist. Phyllomedusin has vasodilating activity and provokes the contraction of the pylorus[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor
Target	NK1
In Vitro	Phyllomedusin increases neuronal excitation with psychoactive and behavioral responses[4]. Phyllomedusin can cause smooth muscle contraction and vasodilatation[4].
In Vivo	Phyllomedusin (30-300 μg/kg, i.p.) delays gastric emptying in conscious rats[2]. Phyllomedusin (0.1 and 5 μg/kg, i.v.) has stimulant activity on the stomach of the anaesthetized rat[3]. Animal Model: Conscious rats[2]. Dosage: 30, 100, 300 μg/kg Administration: Intraperitoneal injection (i.p.) Result: Caused 75% delay in gastric emptying in conscious rats.
References	[1]. Ganjiwale AD, et al. Three-dimensional structure of Phyllomedusin, a NK1 receptor agonist bound to dodecylphosphocholine micelles. J Struct Biol. 2009 Aug;167(2):176-84. [2]. Bertaccini G, et al. Effect of substance P and its natural analogues on gastric emptying of the conscious rat. Br J Pharmacol. 1981 Feb;72(2):221-3. [3]. Bertaccini G, et al. Action of some natural peptides on the stomach of the anaesthetized rat. Naunyn Schmiedebergs Arch Pharmacol. 1977 Jun;298(2):163-6. [4]. Sacco MA, et al. Kambo: Natural drug or potential toxic agent? A literature review of acute poisoning cases. Toxicol Rep. 2022 Apr 15;9:905-913.

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₂H₈₂N₁₆O₁₃S
Molecular Weight	1171.372
Exact Mass	1170.596802
LogP	-1.52
Index of Refraction	1.668

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