72506-14-0

72506-14-0 structure

Name: 3-Methyl-2-butenoic acid [8-hydroxymethyl-1,5-dimethyl-5-(4-methyl-3-pentenyl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl] ester
Chemical Name: (1R,2R,5S,7E,11R)-8-(Hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl 3-methyl-2-butenoate
CAS Number: 72506-14-0
Molecular Formula: C₂₅H₃₈O₄
Molecular Weight: 402.57
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2021-09-10 16:14:29
Modify Date: 2024-01-19 22:03:48
Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor[1].

Name	(1R,2R,5S,7E,11R)-8-(Hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl 3-methyl-2-butenoate
Synonyms	2-Butenoic acid, 3-methyl-, (1R,2R,5S,7E,11R)-8-(hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl ester 2-Butenoic acid, 3-methyl-, (1R,2R,3E,5S,7E,11R)-8-(hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl ester (1R,2R,5S,7E,11R)-8-(Hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl 3-methyl-2-butenoate

Description	Vibsanin A, a protein kinase C (PKC) activator, exhibits anti-proliferative activity against human cancer cell lines. Vibsanin A is also a HSP90 inhibitor[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Signaling Pathways >> Cell Cycle/DNA Damage >> HSP Signaling Pathways >> TGF-beta/Smad >> PKC
References	[1]. Miura K, et, al. Identification of vibsanin A analog as a novel HSP90 inhibitor. Bioorg Med Chem. 2020 Jan 15;28(2):115253. [2]. Shen X, et, al. Vibsanin A sensitizes human acute myeloid leukemia cells to tyrosine kinase inhibitor-induced myeloid differentiation via activation of PKC and upregulation of Lyn. Biochem Biophys Res Commun. 2018 Jul 7;502(1):110-115.