Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Tosufloxacin tosilate
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100490-36-6

100490-36-6 structure

100490-36-6 structure

Name: Tosufloxacin
Chemical Name: tosufloxacin tosilate
CAS Number: 100490-36-6
Molecular Formula: C₁₉H₁₅F₃N₄O₃
Molecular Weight: 404.34300
Catalog: API Synthetic anti-infective drugs Quinolone
Create Date: 2018-04-05 08:00:00
Modify Date: 2024-01-02 18:41:58
Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].

Name	tosufloxacin tosilate
Synonyms	Toskisasin TOSUFLOXACIN TFLX Ozex MFCD01711971 TETRAETHYL AMMONIUM IODIDE TOSUFLOXACIN, ANTIBIOTIC FOR CULTURE MEDIA USE ONLY 1,8-NAPHTHYRIDINE-3-CARBOXYLICACID,7-(3-AMINO-1-PYRROLIDINYL)-1-(2,4-DIFLUOROPHENYL)-6-FLUORO-1,4-DIHYDRO-4-OXO-

Description	Tosufloxacin (A-61827) is an orally active fluoroquinolone antibiotic. Tosufloxacin shows a broad spectrum of antibacterial activity against gram-positive and gram-negative bacteria[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Tosufloxacin tosylate hydrate (T-3262) (0.05-3.13 μg/mL; 18 h) shows antibacterial activities against S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens[2]. Cell Viability Assay[2] Cell Line: S. aureus, Staphylococcus epidermidis, streptococci, enterococci, Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens Concentration: 0.05-3.13 μg/mL Incubation Time: 18 hours Result: Showed MIC90s (MICs for 90% of the isolates tested) ranging from 0.05 to 1.56 μg/mL for S. aureus, Staphylococcus epidermidis, streptococci, and enterococci. Showed MIC90s of 1.56, 3.13, and 0.20 μg/mL for Bacteroides fragilis, Clostridium difficile, and Clostridium perfringens, respectively.
In Vivo	Tosufloxacin tosylate hydrate (T-3262) (oral gavage; 0.16-13.39 mg/kg; once) treatment shows antibacterial activity against S. aureus, E. coli, and P. aeruginosa in vivo[2]. Animal Model: Male Slc:ICR mice infected with S. aureus[2] Dosage: 1.27-2.15 mg/kg Administration: Oral gavage; 1.27-2.15 mg/kg; once Result: Showed 50% effective dose (ED50) of 1.62 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL. Animal Model: Male Slc:ICR mice infected with E. coli[2] Dosage: 0.16-0.30 mg/kg Administration: Oral gavage; 0.16-0.30 mg/kg; once Result: Showed 50% effective dose (ED50) of 0.22 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.0125 μg/mL. Animal Model: Male Slc:ICR mice infected with P. aeruginosa[2] Dosage: 7.66-13.39 mg/kg Administration: Oral gavage; 7.66-13.39 mg/kg; once Result: Showed 50% effective dose (ED50) of 10.13 mg/kg (body weight) at 7 days after infection. Showed MIC value of 0.78 μg/mL.

Density	1.558g/cm3
Boiling Point	614.4ºC at 760 mmHg
Molecular Formula	C₁₉H₁₅F₃N₄O₃
Molecular Weight	404.34300
Flash Point	325.4ºC
Exact Mass	404.11000
PSA	101.45000
LogP	2.80390
Vapour Pressure	5.96E-16mmHg at 25°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QN2791990

CHEMICAL NAME :: 1,8-Naphthyridine-3-carboxylic acid, 1,4-dihydro-7-(3-amino-1-pyrrolidinyl)-1-(2,4- difluorophenyl)-6-fluoro-4-oxo-

CAS REGISTRY NUMBER :: 100490-36-6

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C19-H15-F3-N4-O3

MOLECULAR WEIGHT :: 404.38

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: DNA repair

TEST SYSTEM :: Bacteria - Bacillus subtilis

DOSE/DURATION :: 20 mg/L

REFERENCE :: AMACCQ Antimicrobial Agents and Chemotherapy. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1972- Volume(issue)/page/year: 37,213,1993

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S37/39
WGK Germany	3