1331754-16-5

1331754-16-5 structure

Name: A6770
Chemical Name: A6770
CAS Number: 1331754-16-5
Molecular Formula: C₆H₈N₂O₂
Molecular Weight: 140.140
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2021-06-13 14:28:52
Modify Date: 2024-01-31 18:49:21
A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].

Name	A6770
Synonyms	MFCD28675904 1-[5-(Hydroxymethyl)-1H-imidazol-2-yl]ethanone A6770 Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-

Description	A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Metabolic Disease
In Vitro	A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition[1]. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition[2].
In Vivo	A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2]
References	[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. [2]. Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560.