A6770

Modify Date: 2025-08-27 16:21:05

A6770 structure	Common Name	A6770
	CAS Number	1331754-16-5	Molecular Weight	140.140
	Density	1.3±0.1 g/cm3	Boiling Point	384.1±34.0 °C at 760 mmHg
	Molecular Formula	C₆H₈N₂O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	186.1±25.7 °C

Use of A6770

A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].

Name	A6770
Synonym	More Synonyms

Description	A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Metabolic Disease
In Vitro	A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition[1]. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition[2].
In Vivo	A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2]
References	[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216. [2]. Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560.

Density	1.3±0.1 g/cm3
Boiling Point	384.1±34.0 °C at 760 mmHg
Molecular Formula	C₆H₈N₂O₂
Molecular Weight	140.140
Flash Point	186.1±25.7 °C
Exact Mass	140.058578
LogP	-1.64
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.577

MFCD28675904

1-[5-(Hydroxymethyl)-1H-imidazol-2-yl]ethanone

A6770

Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-

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Shanghai Nianxing Industrial Co., Ltd
China
Product Name: A6770
Price: Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: A6770
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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A6770

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.