A6770
Modify Date: 2025-08-27 16:21:05
A6770 structure
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Common Name | A6770 | ||
|---|---|---|---|---|
| CAS Number | 1331754-16-5 | Molecular Weight | 140.140 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 384.1±34.0 °C at 760 mmHg | |
| Molecular Formula | C6H8N2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 186.1±25.7 °C | |
Use of A6770A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2]. |
| Name | A6770 |
|---|---|
| Synonym | More Synonyms |
| Description | A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2]. |
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| Related Catalog | |
| In Vitro | A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition[1]. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition[2]. |
| In Vivo | A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2] |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 384.1±34.0 °C at 760 mmHg |
| Molecular Formula | C6H8N2O2 |
| Molecular Weight | 140.140 |
| Flash Point | 186.1±25.7 °C |
| Exact Mass | 140.058578 |
| LogP | -1.64 |
| Vapour Pressure | 0.0±0.9 mmHg at 25°C |
| Index of Refraction | 1.577 |
| InChIKey | JXDVIQLWMKAZBS-UHFFFAOYSA-N |
| SMILES | CC(=O)c1ncc(CO)[nH]1 |
| MFCD28675904 |
| 1-[5-(Hydroxymethyl)-1H-imidazol-2-yl]ethanone |
| A6770 |
| Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]- |