A6770

Names

[ Name ]:
A6770

[Synonym ]:
MFCD28675904
1-[5-(Hydroxymethyl)-1H-imidazol-2-yl]ethanone
A6770
Ethanone, 1-[5-(hydroxymethyl)-1H-imidazol-2-yl]-

Biological Activity

[Description]:

A6770 is an orally active, potent sphingosine 1-phosphate (S1P) lyase (S1PL) inhibitor. A6770 is phosphorylated and the phosphorylated form directly inhibits S1P lyased.A6770, a potential key metabolite of THI, induces a [3H]dhS1P increase[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> LPL Receptor

Research Areas >> Metabolic Disease

[In Vitro]

A6770 causes concentration-dependent increases in [3H] dhS1P with the EC50 ranging from 30 to 200 μM under the normal condition[1]. A6770 leads to S1PL inhibition rather than SPHK activation or SPP inhibition[2].

[In Vivo]

A6770 (1, 10, 100mg/kg; po; single dose) induces reductions in peripheral lymphocyte number in rats[2]

[References]

[1]. Mamoru Ohtoyo, et al. Scintillation Proximity Assay to Detect the Changes in Cellular Dihydrosphingosine 1-Phosphate Levels. Lipids. 2016 Oct;51(10):1207-1216.

[2]. Mamoru Ohtoyo, et al. Component of Caramel Food Coloring, THI, Causes Lymphopenia Indirectly via a Key Metabolic Intermediate. Cell Chem Biol. 2016 May 19;23(5):555-560.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
384.1±34.0 °C at 760 mmHg

[ Molecular Formula ]:
C₆H₈N₂O₂

[ Molecular Weight ]:
140.140

[ Flash Point ]:
186.1±25.7 °C

[ Exact Mass ]:
140.058578

[ LogP ]:
-1.64

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.577

Related Compounds

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