1423381-07-0
1423381-07-0 structure
- Name: Pep2m, myristoylated
- Chemical Name: Pep2m, myristoylated
- CAS Number: 1423381-07-0
- Molecular Formula: C63H118N18O14S
- Molecular Weight: 1383.788
- Catalog: Signaling Pathways Epigenetics PKC
- Create Date: 2021-05-05 16:21:39
- Modify Date: 2024-01-13 09:03:57
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Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2].
| Name | Pep2m, myristoylated |
|---|---|
| Synonyms |
N2-Tetradecanoyl-L-lysyl-L-arginyl-L-methionyl-L-lysyl-L-valyl-L-alanyl-L-lysyl-L-asparaginyl-L-alanyl-L-glutamine
L-Glutamine, N2-(1-oxotetradecyl)-L-lysyl-L-arginyl-L-methionyl-L-lysyl-L-valyl-L-alanyl-L-lysyl-L-asparaginyl-L-alanyl- |
| Description | Pep2m, myristoylated (Myr-Pep2m) is a cell-permeable peptide. Pep2m, myristoylated can disrupt the protein kinase ζ (PKMζ) downstream targets, N-ethylmaleimide-sensitive factor/glutamate receptor subunit 2 (NSF/GluR2) interactions. PKMζ is an autonomously active isozyme of protein kinase C (PKC)[1][2]. |
|---|---|
| Related Catalog | |
| Target |
NSF/GluR2 interactions[1] |
| In Vitro | Pep2m, myristoylated (10 μM) blocks PKMζ-mediated AMPA receptor (AMPAR) potentiation[1]. Pep2m, myristoylated does not block the increase of PKMζ in the hippocampal slices during long-term potentiation (LTP) maintenance, indicating that blocking NSF/GluR2 interactions do not prevent the induction of PKMζ synthesis[1]. Pep2m, myristoylated blocks NSF/GluR2-mediated AMPAR trafficking, and reverses persistent potentiation at both the strongly stimulates synapses and the weakly stimulats synapses that underwent synaptic tagging and capture[1]. |
| In Vivo | Pep2m, myristoylated (10 µg) results in an increase in paw withdrawal thresholds (PWTs) on nociceptive responses in the formalin test[2]. Animal Model: Female and male Long-Evans hooded rats (8 weeks)[2] Dosage: 10 µg (in 20 µL) Administration: Intrathecal injection Result: Resulted in an increase in PWTs, in both male and female rats at various time points tested. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C63H118N18O14S |
| Molecular Weight | 1383.788 |
| Exact Mass | 1382.879517 |
| LogP | 0.81 |
| Index of Refraction | 1.605 |