161922-40-3
161922-40-3 structure
- Name: Acivicin hydrochloride
- Chemical Name: Acivicin hydrochloride
- CAS Number: 161922-40-3
- Molecular Formula: C5H8Cl2N2O3
- Molecular Weight: 215.03
- Catalog: Research Areas Infection
- Create Date: 2021-01-08 22:45:10
- Modify Date: 2024-01-16 16:16:42
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Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2].
| Name | Acivicin hydrochloride |
|---|
| Description | Acivicin hydrochloride (AT-125 hydrochloride), a natural product produced by Streptomyces sviceus, is a γ−glutamyl transpeptidase (GGT) inhibitor. Acivicin hydrochloride can across the blood-brain barrier and has anti-cancer, anti-parasitic properties[1][2]. |
|---|---|
| Related Catalog | |
| Target |
γ−glutamyl transpeptidase[1] |
| In Vitro | Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days) has an IC50 of 0.7 μM in human HepG2 cells[1]. |
| In Vivo | Acivicin hydrochloride (AT-125 hydrochloride; 0.1-50 μM; 5 days; for 4 days) reduces urinary gamma-GT by 70-78%[1]. Animal Model: Male pigmented Long-Evans rats weighed between 250 g and 300 g exposed to Toluene[1] Dosage: 5 mg/kg Administration: IP; twice weekly (monday and wednesday); for 4 days Result: Reduced urinary gamma-GT by 70-78%. |
| References |
| Molecular Formula | C5H8Cl2N2O3 |
|---|---|
| Molecular Weight | 215.03 |