42228-92-2

Harmful by inhalation, in contact with skin and if swallowed.

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3 - Composition/Information on Ingredients

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Product NameCAS #EC noAnnex I
Index Number
ACIVICIN42228-92-2 NoneNone
FormulaC5H7ClN2O3
Molecular Weight 178,6000 AMU
SynonymsAcivicine *
(alpha-S,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-i
soxazoleacetic acid * Antibiotic AT 125 * AT 125
*
(S-(R*,R*))-4,5-Dihydro-alpha-amino-3-chloro-5-is
oxazoleacetic acid * NSC-163501 * U 42126

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4 - First Aid Measures

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AFTER INHALATION
If inhaled, remove to fresh air. If breathing becomes difficult,
call a physician.
AFTER SKIN CONTACT
In case of skin contact, flush with copious amounts of water for
at least 15 minutes. Remove contaminated clothing and shoes.
Call a physician.
AFTER EYE CONTACT
In case of contact with eyes, flush with copious amounts of
water for at least 15 minutes. Assure adequate flushing by
separating the eyelids with fingers. Call a physician.
SIGMAwww.molbase.com
AFTER INGESTION
If swallowed, wash out mouth with water provided person is
conscious. Call a physician.

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5 - Fire Fighting Measures

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EXTINGUISHING MEDIA
Suitable: Water spray. Carbon dioxide, dry chemical powder, or
appropriate foam.
SPECIAL PROTECTIVE EQUIPMENT FOR FIREFIGHTERS
Wear self-contained breathing apparatus and protective clothing
to prevent contact with skin and eyes.

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6 - Accidental Release Measures

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PROCEDURE(S) OF PERSONAL PRECAUTION(S)
Wear respirator, chemical safety goggles, rubber boots, and
heavy rubber gloves.
METHODS FOR CLEANING UP
Sweep up, place in a bag and hold for waste disposal. Avoid
raising dust. Ventilate area and wash spill site after material
pickup is complete.

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7 - Handling and Storage

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STORAGE
Store at 2-8°C

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8 - Exposure Controls / Personal Protection

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ENGINEERING CONTROLS
Mechanical exhaust required.
PERSONAL PROTECTIVE EQUIPMENT
Special Protective Measures: Wear appropriate government approved
respirator, chemical-resistant gloves, safety goggles, other
protective clothing.

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9 - Physical and Chemical Properties

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AppearancePhysical State: Solid
PropertyValueAt Temperature or Pressure
pHN/A
BP/BP RangeN/A
MP/MP RangeN/A
Flash PointN/A
FlammabilityN/A
Autoignition TempN/A
Oxidizing PropertiesN/A
Explosive PropertiesN/A
Explosion LimitsN/A
Vapor PressureN/A
Partition CoefficientN/A
ViscosityN/A
Vapor DensityN/A
Saturated Vapor Conc.N/A
SIGMAwww.molbase.com
Evaporation RateN/A
Bulk DensityN/A
Decomposition Temp.N/A
Solvent ContentN/A
Water ContentN/A
Surface TensionN/A
ConductivityN/A
Miscellaneous DataN/A
SolubilityN/A

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10 - Stability and Reactivity

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STABILITY
Stable: Stable.
HAZARDOUS DECOMPOSITION PRODUCTS
Hazardous Decomposition Products: Carbon monoxide, Carbon dioxide,
Nitrogen oxides, Hydrogen chloride gas.
HAZARDOUS POLYMERIZATION
Hazardous Polymerization: Will not occur

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11 - Toxicological Information

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RTECS NUMBER: NY2103000
SIGNS AND SYMPTOMS OF EXPOSURE
Exposure can cause gastrointestinal disturbances, nausea,
diarrhea, vomiting, myelosuppression, nightmares,
hallucinations, paranoia, hematopoietic toxicity, and adverse
CNS effects. In males, exposure can cause adverse effects on the
reproductive system causing cessation of sperm production and
degeneration of the testicles and of the seminiferous tubules.
ROUTE OF EXPOSURE
Multiple Routes: Harmful if swallowed, inhaled, or absorbed
through skin.
CHRONIC EXPOSURE - MUTAGEN
Mouse
250 MG/KG
Intraperitoneal
Micronucleus test
Chicken
6 UMOL/L
Cell Type: Embryo
DNA inhibition

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12 - Ecological Information

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No data available.

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13 - Disposal Considerations

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SUBSTANCE DISPOSAL
Dissolve or mix the material with a combustible solvent and burn
in a chemical incinerator equipped with an afterburner and
scrubber. Observe all federal, state, and local environmental
SIGMAwww.molbase.com
regulations.

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14 - Transport Information

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RID/ADR
Non-hazardous for road transport.
IMDG
Non-hazardous for sea transport.
IATA
Non-hazardous for air transport.

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15 - Regulatory Information

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CLASSIFICATION AND LABELING ACCORDING TO EU DIRECTIVES
INDICATION OF DANGER: Xn
Harmful.
R-PHRASES: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.
S-PHRASES: 36
Wear suitable protective clothing.
Caution: Substance not yet fully tested (EU).
COUNTRY SPECIFIC INFORMATION
Germany
WGK: 3
Self-Classification

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16 - Other Information

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WARRANTY
The above information is believed to be correct but does not
purport to be all inclusive and shall be used only as a guide. The
information in this document is based on the present state of our
knowledge and is applicable to the product with regard to
appropriate safety precautions. It does not represent any
guarantee of the properties of the product. Inc.,
shall not be held liable for any damage resulting from handling or
from contact with the above product. See reverse side of invoice
or packing slip for additional terms and conditions of sale.
Copyright 2010 Co. License granted to make
unlimitedpaper copies for internal use only.
DISCLAIMER
For R&D use only. Not for drug, household or other uses.
SIGMAwww.molbase.com

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SECTION 16 - ADDITIONAL INFORMATION
N/A

MOLECULAR FORMULA :

C5-H7-Cl-N2-O3

MOLECULAR WEIGHT :

178.59

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :

Micronucleus test

MUTATION DATA

TYPE OF TEST :

DNA inhibition

TEST SYSTEM :

Bird - chicken Embryo

DOSE/DURATION :

6 umol/L

REFERENCE :

JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,633,1983