2077980-83-5
2077980-83-5 structure
- Name: GLL398
- Chemical Name: (2E)-3-(4-{(1E)-1-[4-(Dihydroxyboryl)phenyl]-2-phenyl-1-buten-1-yl}phenyl)acrylic acid
- CAS Number: 2077980-83-5
- Molecular Formula: C25H23BO4
- Molecular Weight: 398.259
- Create Date: 2021-01-07 11:06:58
- Modify Date: 2025-09-11 10:14:56
-
GLL398 is an Oral Selective Estrogen Receptor Downregulator. GLL398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1.14 nM) and potently degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). Most importantly, the introduction of the boronic acid group confers superior oral bioavailability of GLL398 (AUC = 36.9 μg·h/mL) in rats as compared to GW7604 (AUC = 3.35 μg·h/mL). The strikingly favorable pharmacokinetic property of GLL398 makes it a promising oral SERD suitable for clinical evaluation.
| Name | (2E)-3-(4-{(1E)-1-[4-(Dihydroxyboryl)phenyl]-2-phenyl-1-buten-1-yl}phenyl)acrylic acid |
|---|---|
| Synonyms |
2-Propenoic acid, 3-[4-[(1E)-1-(4-boronophenyl)-2-phenyl-1-buten-1-yl]phenyl]-, (2E)-
(2E)-3-(4-{(1E)-1-[4-(Dihydroxyboryl)phenyl]-2-phenyl-1-buten-1-yl}phenyl)acrylic acid |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.7±65.0 °C at 760 mmHg |
| Molecular Formula | C25H23BO4 |
| Molecular Weight | 398.259 |
| Flash Point | 318.3±34.3 °C |
| Exact Mass | 398.168945 |
| LogP | 7.64 |
| Vapour Pressure | 0.0±1.8 mmHg at 25°C |
| Index of Refraction | 1.646 |