2077980-83-5

• 常用中文名：GLL398
• 常用英文名：GLL398
• CAS号：2077980-83-5
• 分子式：C₂₅H₂₃BO₄
• 分子量：398.259
• 发布时间：2021-01-07 11:06:58
• 更新时间：2025-09-11 10:14:56
• GLL398 is an Oral Selective Estrogen Receptor Downregulator. GLL398 strongly binds to ERα in a fluorescence resonance energy transfer binding assay (IC50 =1.14 nM) and potently degrades ERα in MCF-7 breast cancer cells (IC50 = 0.21 μM). Most importantly, the introduction of the boronic acid group confers superior oral bioavailability of GLL398 (AUC = 36.9 μg·h/mL) in rats as compared to GW7604 (AUC = 3.35 μg·h/mL). The strikingly favorable pharmacokinetic property of GLL398 makes it a promising oral SERD suitable for clinical evaluation.

名称

• 英文名: (2E)-3-(4-{(1E)-1-[4-(Dihydroxyboryl)phenyl]-2-phenyl-1-buten-1-yl}phenyl)acrylic acid
• 英文别名: 2-Propenoic acid, 3-[4-[(1E)-1-(4-boronophenyl)-2-phenyl-1-buten-1-yl]phenyl]-, (2E)-; (2E)-3-(4-{(1E)-1-[4-(Dihydroxyboryl)phenyl]-2-phenyl-1-buten-1-yl}phenyl)acrylic acid

物化性质

• 密度: 1.2±0.1 g/cm3
• 沸点: 602.7±65.0 °C at 760 mmHg
• 分子式: C₂₅H₂₃BO₄
• 分子量: 398.259
• 闪点: 318.3±34.3 °C
• 精确质量: 398.168945
• LogP: 7.64
• 蒸汽压: 0.0±1.8 mmHg at 25°C
• 折射率: 1.646