2077980-80-2

2077980-80-2 structure

Name: GLL398
Chemical Name: GLL398
CAS Number: 2077980-80-2
Molecular Formula: C₂₅H₂₃BO₄
Molecular Weight: 398.3
Catalog: Research Areas Cancer
Create Date: 2018-07-20 16:38:25
Modify Date: 2025-09-11 09:44:46
GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1].

Name	GLL398

Description	GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Cancer
In Vitro	GLL398 is a boron-modified GW5638 analog[1].
References	[1]. Guo S, et al. GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models. Breast Cancer Res Treat. 2020;180(2):359-368.