2077980-80-2
2077980-80-2 structure
- Name: GLL398
- Chemical Name: GLL398
- CAS Number: 2077980-80-2
- Molecular Formula:
- Molecular Weight:
- Catalog: Research Areas Cancer
- Create Date: 2018-07-20 16:38:25
- Modify Date: 2024-09-03 20:07:06
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GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1].
| Name | GLL398 |
|---|
| Description | GLL398, an orally active selective estrogen receptor degrader (SERD), competitively binds to the estrogen receptor with an IC50 value of 1.14 nM. GLL398 exhibits a strong dose-dependent binding profile for the ER with a Y537S point mutation (IC50= 29.5 nM). GLL398 blocks tumor growth in xenograft breast cancer models[1]. |
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| Related Catalog | |
| In Vitro | GLL398 is a boron-modified GW5638 analog[1]. |
| References |
| No Any Chemical & Physical Properties |