1867107-62-7

1867107-62-7 structure

Name: RA-2
Chemical Name: RA-2
CAS Number: 1867107-62-7
Molecular Formula: C₂₂H₁₆F₂O₆
Molecular Weight: 414.356
Create Date: 2021-01-16 09:39:32
Modify Date: 2024-01-16 15:48:33
RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].

Name	RA-2
Synonyms	1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate RA-2 1,3-Phenylenebis(methylene) bis(3-fluoro-4-hydroxybenzoate) Benzoic acid, 3-fluoro-4-hydroxy-, 1,3-phenylenebis(methylene) ester 1,1'-[1,3-Phenylenebis(methylene)]-3-fluoro-4-hydroxy-benzoic acid ester

Description	RA-2 is a negative-gating modulator of KCa2/3 channels with an IC50 of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation[1].
Related Catalog	Research Areas >> Cardiovascular Disease Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
References	[1]. Oliván-Viguera A, et al. A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol Pharmacol. 2015;87(2):338-348.