1832713-02-6
1832713-02-6 structure
- Name: RA 839
- Chemical Name: (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid
- CAS Number: 1832713-02-6
- Molecular Formula: C25H28N2O4S
- Molecular Weight: 452.566
- Create Date: 2020-01-11 19:30:51
- Modify Date: 2024-01-17 19:54:35
-
A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice.
| Name | (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid |
|---|---|
| Synonyms |
MFCD30182350
(3s)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}naphthalen-1-Yl)pyrrolidine-3-Carboxylic Acid 3-Pyrrolidinecarboxylic acid, 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-, (3S)- (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid |
| Description | A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice. |
|---|---|
| References | References 1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55. 2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529. View Related Products by Target Keap1-Nrf2 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 707.9±70.0 °C at 760 mmHg |
| Molecular Formula | C25H28N2O4S |
| Molecular Weight | 452.566 |
| Flash Point | 381.9±35.7 °C |
| Exact Mass | 452.176971 |
| LogP | 4.94 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.656 |