RA 839
Modify Date: 2024-01-17 19:54:35
RA 839 structure
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Common Name | RA 839 | ||
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| CAS Number | 1832713-02-6 | Molecular Weight | 452.566 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 707.9±70.0 °C at 760 mmHg | |
| Molecular Formula | C25H28N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 381.9±35.7 °C | |
Use of RA 839A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice. |
| Name | (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid |
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| Synonym | More Synonyms |
| Description | A noncovalent small molecule binder to Keap1 (Kd=6 uM) and selective activator of Nrf2 signaling; binds noncovalently to the Nrf2-interacting kelch domain of Keap1, significantly regulates 105 probe sets in bone marrow-derived macrophages at 10 uM; prevents the induction of both iNOS expression and nitric oxide release in response to lipopolysaccharides in macrophages; acutely induces Nrf2 target gene expression in liver in mice. |
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| References | References 1. Winkel AF, et al. J Biol Chem. 2015 Nov 20;290(47):28446-55. 2. Nasiri HR, et al. Bioorg Med Chem Lett. 2016 Jan 15;26(2):526-529. View Related Products by Target Keap1-Nrf2 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 707.9±70.0 °C at 760 mmHg |
| Molecular Formula | C25H28N2O4S |
| Molecular Weight | 452.566 |
| Flash Point | 381.9±35.7 °C |
| Exact Mass | 452.176971 |
| LogP | 4.94 |
| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
| Index of Refraction | 1.656 |
| MFCD30182350 |
| (3s)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}naphthalen-1-Yl)pyrrolidine-3-Carboxylic Acid |
| 3-Pyrrolidinecarboxylic acid, 1-[4-[[(2,3,5,6-tetramethylphenyl)sulfonyl]amino]-1-naphthalenyl]-, (3S)- |
| (3S)-1-(4-{[(2,3,5,6-Tetramethylphenyl)sulfonyl]amino}-1-naphthyl)-3-pyrrolidinecarboxylic acid |