1782573-67-4
1782573-67-4 structure
- Name: RU-SKI43 HCl
- Chemical Name: RU-SKI 43 (hydrochloride)
- CAS Number: 1782573-67-4
- Molecular Formula: C22H31ClN2O2S
- Molecular Weight: 423.012
- Create Date: 2021-01-09 10:12:14
- Modify Date: 2025-11-25 16:56:15
-
RU-SKI 43 is an inhibitor of Hat. It blocks palmitoylation of Shh without affecting palmitoylation of H-Ras or Fyn, myristoylation of c-Src, or acylation of Wnt3a. RU-SKI-43 reduced pancreatic cancer cell proliferation and Gli-1 activation through Smoothened-independent non-canonical signaling. In addition, RU-SKI 43 treatment inhibited two key proliferative pathways regulated by Akt and mTOR.
| Name | RU-SKI 43 (hydrochloride) |
|---|---|
| Synonyms |
2-[(2-Methylbutyl)amino]-1-{4-[(3-methylphenoxy)methyl]-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl}ethanone hydrochloride (1:1)
MFCD25371547 Ethanone, 1-[6,7-dihydro-4-[(3-methylphenoxy)methyl]thieno[3,2-c]pyridin-5(4H)-yl]-2-[(2-methylbutyl)amino]-, hydrochloride (1:1) RU-SKI 43 (hydrochloride) |
| Molecular Formula | C22H31ClN2O2S |
|---|---|
| Molecular Weight | 423.012 |
| Exact Mass | 422.179474 |