Shanghai Nianxing Industrial Co., Ltd
China
Product Name: TRC-766
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: TRC-766
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

1810734-44-1

1810734-44-1 structure

1810734-44-1 structure

Name: TRC-766
Chemical Name: TRC-766
CAS Number: 1810734-44-1
Molecular Formula: C₂₅H₂₄ClF₃N₂O₃S
Molecular Weight: 524.98
Catalog: Research Areas Others
Create Date: 2021-01-09 12:01:08
Modify Date: 2025-08-25 20:20:38
TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].

Name	TRC-766

Description	TRC-766 is a negative control of RTC-5 (TRC-382). TRC-766 binds protein phosphatase 2A (PP2A) and does not activate the phosphatase[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	As a pharmacologic control, the cells are treated with increasing doses of TRC-766, which is structurally similar to PP2A (SMAP) but biologically inactive. TRC-766 lacks a key N-H sulfonamide hydrogen bond donor. While TRC-766 still binds PP2A, it does not activate the phosphatase and therefore it was postulated to not affect cell viability[1].
References	[1]. Kimberly McClinch, et al. Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer. Cancer Res. 2018 Apr 15;78(8):2065-2080.

Molecular Formula	C₂₅H₂₄ClF₃N₂O₃S
Molecular Weight	524.98

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