1596362-29-6
1596362-29-6 structure
- Name: PS372424 hydrochloride
- Chemical Name: PS372424 hydrochloride
- CAS Number: 1596362-29-6
- Molecular Formula: C33H45ClN6O4
- Molecular Weight: 625.20
- Catalog: Signaling Pathways GPCR/G Protein CXCR
- Create Date: 2020-11-24 16:59:28
- Modify Date: 2024-01-07 18:04:49
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PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation[1][2].
| Name | PS372424 hydrochloride |
|---|
| Description | PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation[1][2]. |
|---|---|
| Related Catalog | |
| Target |
Human CXCR3 |
| In Vitro | PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation[1]. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[2]. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM[3]. Western Blot Analysis[2] Cell Line: CXCR3+ T cells and CXCR3- T cells Concentration: 10, 50, 100, or 200 nM Incubation Time: 30 minutes Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells. |
| References |
| Molecular Formula | C33H45ClN6O4 |
|---|---|
| Molecular Weight | 625.20 |