PS372424 hydrochloride
Modify Date: 2024-01-07 18:04:49
PS372424 hydrochloride structure
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Common Name | PS372424 hydrochloride | ||
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| CAS Number | 1596362-29-6 | Molecular Weight | 625.20 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C33H45ClN6O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PS372424 hydrochloridePS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation[1][2]. |
| Name | PS372424 hydrochloride |
|---|
| Description | PS372424 hydrochloride, a three amino-acid fragment of CXCL10, is a specific human CXCR3 agonist with anti-inflammatory activity. PS372424 hydrochloride prevents human T-cell migration in a humanized model of arthritic inflammation[1][2]. |
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| Related Catalog | |
| Target |
Human CXCR3 |
| In Vitro | PS372424 (100 ng/mL) increases p-Erk1 and p-Erk2 in U87-CXCR3-A cells after 5 min of stimulation[1]. PS372424 (10-200 nM; 30 min) causes a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells not in CXCR3- T cells[2]. PS372424 competes for binding of radiolabeled CXCL10 to membranes prepared from HEK293/CXCR3 Gqi5 cells with an IC50 of 42±21 nM[3]. Western Blot Analysis[2] Cell Line: CXCR3+ T cells and CXCR3- T cells Concentration: 10, 50, 100, or 200 nM Incubation Time: 30 minutes Result: Caused a concentration-dependent phosphorylation of CCR5 on CXCR3+ T cells. Did not result in phosphorylation of CCR5 on CXCR3- T cells. |
| References |
| Molecular Formula | C33H45ClN6O4 |
|---|---|
| Molecular Weight | 625.20 |