174688-78-9
174688-78-9 structure
- Name: CH 275
- Chemical Name: CH 275
- CAS Number: 174688-78-9
- Molecular Formula: C74H96N14O15S2
- Molecular Weight: 1485.77
- Catalog: Signaling Pathways GPCR/G Protein Somatostatin Receptor
- Create Date: 2020-08-07 16:40:35
- Modify Date: 2024-01-10 11:24:53
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CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively[1]. CH 275 can be used for the research of Alzheimer’s disease[2].
| Name | CH 275 |
|---|
| Description | CH 275 is a potent and selective somatostatin receptor 1 (sst1) agonist and display IC50 values of 30.9 nM, 345 nM, >1 μM, >10 μM for human human sst1, sst3, sst4, sst2 and sst5 respectively[1]. CH 275 can be used for the research of Alzheimer’s disease[2]. |
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| Related Catalog | |
| In Vitro | CH275 (100 nM) activates neprilysin activity, wheras treatment with cyclo-SRIF can complete this activation in vitro in primary neuron-based cell culture system, a mixture of wildtype hippocampal, cortical and striatal neuron[1]. |
| In Vivo | CH275 (osmotic pump administration; 56 μM; two weeks) decreases the level of neprilysin/SRIF in the App knock-in mice[1]. CH275 directly injects into the Lmol layer of 2-month-old AppNL-G-Fmice for four months. AppNL-G-F mice begin to exhibit Aβ plaques at two months of age, but CH275 leads to robustly increased the expression of neprilysin in hippocampus which is paralleled by a clear reduction in Aβ plaque load in the same region, and without causing any toxic side effects[1]. |
| References |
| Molecular Formula | C74H96N14O15S2 |
|---|---|
| Molecular Weight | 1485.77 |