534605-78-2
534605-78-2 structure
- Name: CH-0793076
- Chemical Name: CH-0793076
- CAS Number: 534605-78-2
- Molecular Formula: C26H26N4O4
- Molecular Weight: 458.51
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
- Create Date: 2020-04-09 17:55:08
- Modify Date: 2025-08-28 22:32:16
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CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein)[1].
| Name | CH-0793076 |
|---|
| Description | CH-0793076 (TP3076), a hexacyclic camptothecin analog, is active drug and major metabolite of TP300. CH-0793076 inhibits DNA topoisomerase I with an IC50 of 2.3 μM. CH-0793076 is efficacious against cells expressing BCRP (breast cancer resistance protein)[1]. |
|---|---|
| Related Catalog | |
| Target |
Topoisomerase I:2.3 μM (IC50) |
| In Vitro | CH0793076 (TP3076) (6 days at 37°C) shows antiproliferative activity against PC-6/BCRP and PC-6/pRC cells, with IC50 of 0.35 and 0.18 nM[1]. |
| In Vivo | TP300 (1-100 mg/kg; bolus intravenous injection once per week for 3 weeks, for a total of three doses) shows more than 50% of tumor growth inhibition in all nine models, regardless of the expression of BCRP (WiDr, HT-29, NCI-H460 and AsPC-1, HCT116, COLO 201, HCT-15, Calu-6 and NCI-N87)[1]. |
| References |
| Molecular Formula | C26H26N4O4 |
|---|---|
| Molecular Weight | 458.51 |