2109704-99-4
2109704-99-4 structure
- Name: Belumosudil mesylate
- Chemical Name: Belumosudil mesylate
- CAS Number: 2109704-99-4
- Molecular Formula: C27H28N6O5S
- Molecular Weight: 548.61
- Catalog: Signaling Pathways Cell Cycle/DNA Damage ROCK
- Create Date: 2020-08-11 15:05:50
- Modify Date: 2024-01-10 15:30:50
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Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1].
| Name | Belumosudil mesylate |
|---|
| Description | Belumosudil mesylate (KD025 mesylate) is a selective inhibitor of ROCK2 with IC50s of 105 nM and 24 µM for ROCK2 and ROCK1, respectively. Anti-fibrotic properties[1]. |
|---|---|
| Related Catalog | |
| Target |
ROCK2:105 nM (IC50) ROCK1:24 μM (IC50) |
| In Vitro | Belumosudil (SLx-2119; 40 µM) induces significant down-regulations of Tsp-1 and CTGF mRNA levels in PASMC. The microarray hybridized with aRNA from HMVEC treated with Belumosudil, shows a 5-times higher background than the other arrays[1]. |
| In Vivo | Belumosudil (KD-025; 100, 200 or 300 mg/kg, i.p.) dose-dependently reduces infarct volume after transient middle cerebral artery occlusion. Belumosudil is at least as efficacious in aged, diabetic or female mice, as in normal adult males[2]. |
| References |
| Molecular Formula | C27H28N6O5S |
|---|---|
| Molecular Weight | 548.61 |