1085822-09-8

1085822-09-8 structure

Name: TMCB
Chemical Name: CK2/ERK8-IN-1
CAS Number: 1085822-09-8
Molecular Formula: C₁₁H₉Br₄N₃O₂
Molecular Weight: 534.82
Catalog: Signaling Pathways Apoptosis Apoptosis
Create Date: 2020-06-04 15:03:50
Modify Date: 2024-01-09 10:27:52
CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].

Name	CK2/ERK8-IN-1

Description	CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> Pim Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> MAPK/ERK Pathway >> ERK Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> ERK
Target	CK2:0.5 μM (IC50) CK2:0.25 μM (Ki) ERK8:0.5 μM (IC50) PIM1:8.65 μM (Ki) HIPK2:15.25 μM (Ki) DYRK1A:11.9 μM (Ki) Apoptosis
In Vitro	CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells[1]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 0-50 µM Incubation Time: 24 hours Result: Inhibited cell growth in a dose-dependent manner.
References	[1]. Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.

Molecular Formula	C₁₁H₉Br₄N₃O₂
Molecular Weight	534.82