TMCB
Modify Date: 2024-01-09 10:27:52
TMCB structure
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Common Name | TMCB | ||
|---|---|---|---|---|
| CAS Number | 1085822-09-8 | Molecular Weight | 534.82 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H9Br4N3O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of TMCBCK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1]. |
| Name | CK2/ERK8-IN-1 |
|---|
| Description | CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1]. |
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| Related Catalog | |
| Target |
CK2:0.5 μM (IC50) CK2:0.25 μM (Ki) ERK8:0.5 μM (IC50) PIM1:8.65 μM (Ki) HIPK2:15.25 μM (Ki) DYRK1A:11.9 μM (Ki) Apoptosis |
| In Vitro | CK2/ERK8-IN-1 (Compound K66; 0-50 µM; 24 hours; Jurkat cells) treatment displays cytotoxic activity in Jurkat cells[1]. Cell Viability Assay[1] Cell Line: Jurkat cells Concentration: 0-50 µM Incubation Time: 24 hours Result: Inhibited cell growth in a dose-dependent manner. |
| References |
| Molecular Formula | C11H9Br4N3O2 |
|---|---|
| Molecular Weight | 534.82 |