1679371-59-5

1679371-59-5 structure

Name: BMT-124110
Chemical Name: BMT-124110
CAS Number: 1679371-59-5
Molecular Formula: C₂₁H₂₇N₃O₃
Molecular Weight: 369.46
Catalog: Research Areas Neurological Disease
Create Date: 2020-06-01 12:13:22
Modify Date: 2024-01-10 22:26:40
BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].

Name	BMT-124110

Description	BMT-124110 is a potent, selective AAK1 inhibitor with an IC50 of 0.9 nM. BMT-124110 shows antinociceptive activity. BMT-090605 inhibits BMP-2-inducible protein kinase (BIKE) and Cyclin G-associated kinase (GAK) with IC50s of 17 and 99 nM, respectively[1].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	BMT-124110 shows a cellular IC50 of 3.2±1.4 nM for AAK1[1].
In Vivo	BMT-124110 is added directly onto the spinal corevd by microiontophoresis, leading to reduction in windup-induced activity in 10 of 14 animals[1].
References	[1]. Kostich W, et al. Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain. J Pharmacol Exp Ther. 2016 Sep;358(3):371-86.

Molecular Formula	C₂₁H₂₇N₃O₃
Molecular Weight	369.46