1642112-32-0

1642112-32-0 structure

Name: AMG8380
Chemical Name: AMG8380
CAS Number: 1642112-32-0
Molecular Formula: C₂₅H₁₆ClF₂N₃O₅S
Molecular Weight: 543.93
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Sodium Channel
Create Date: 2020-06-01 15:33:35
Modify Date: 2024-04-03 17:20:55
AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1].

Name	AMG8380

Description	AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease
In Vivo	Animal Model: C57Bl/6 male mice[1] Dosage: 100 mg/kg Administration: oral Result: Failed to show a statistically significant effect on scratching behavior.
References	[1]. Kornecook TJ, et al. Pharmacologic Characterization of AMG8379, a Potent and Selective Small Molecule Sulfonamide Antagonist of the Voltage-Gated Sodium Channel NaV1.7. J Pharmacol Exp Ther. 2017 Jul;362(1):146-160.

Molecular Formula	C₂₅H₁₆ClF₂N₃O₅S
Molecular Weight	543.93