AMG8380
Modify Date: 2024-04-03 17:20:55
AMG8380 structure
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Common Name | AMG8380 | ||
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| CAS Number | 1642112-32-0 | Molecular Weight | 543.93 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H16ClF2N3O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AMG8380AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1]. |
| Name | AMG8380 |
|---|
| Description | AMG8380, an orally active and less active enantiomer of AMG8379, can serves as a negative control. AMG8380 inhibits human and mouse voltage-gated sodium channel NaV1.7 with IC50s of 0.907 and 0.387 μM, respectively. AMG8380 blocks Tetrodotoxin (TTX)-sensitive native channels with an IC50 of 2560 nM[1]. |
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| Related Catalog | |
| In Vivo | Animal Model: C57Bl/6 male mice[1] Dosage: 100 mg/kg Administration: oral Result: Failed to show a statistically significant effect on scratching behavior. |
| References |
| Molecular Formula | C25H16ClF2N3O5S |
|---|---|
| Molecular Weight | 543.93 |